Inflammatory cytokine expression in Fabry disease: impact of disease phenotype and alterations under enzyme replacement therapy
ICs were upregulated in FD patients, indicating the role of the innate immune process in FD etiology. ERT ameliorated FD-related inflammatory activation, at least to some extent. IC expression was positively correlated with disease burden and clinical markers in FD. Our findings indicated that the inflammatory pathway may be a promising therapeutic target for FD.
Authors
- Wei Ma (ORCID: https://orcid.org/0000-0002-1561-6735)
- Yujing Yuan
- Yun Yuan (ORCID: https://orcid.org/0000-0003-4736-199X)
- Fan Li (ORCID: https://orcid.org/0000-0001-9043-1119)
- Chen Ling (ORCID: https://orcid.org/0000-0001-5123-936X)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-6241-4207)
- Zhaoxia Wang (ORCID: https://orcid.org/0000-0002-8723-4242)
- Yawen Zhao (ORCID: https://orcid.org/0000-0002-7585-3329)
- Hong-Jun Hao (ORCID: https://orcid.org/0000-0001-6434-9090)
- Yuan Wu
Institutions
- Peking University (CN)
- Beijing Institute of Neurosurgery (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1367252
- Citations
- 6
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Peking University First Hospital
- Peking University