TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in head and neck squamous cell carcinoma
Our research elucidates the TME in HNSCC before and after immunotherapy, revealing a novel mechanism by which TP63<sup>+</sup> SLC7A5<sup>+</sup> HNSCC inhibits ferroptosis and enhances tumor resistance via TP63-induced SLC7A5 upregulation. These insights lay the foundation for the development of more effective treatments for HNSCC.
Authors
- Weiwei Ye (ORCID: https://orcid.org/0000-0003-3719-8455)
- Gengming Cai (ORCID: https://orcid.org/0000-0002-5144-1637)
- Yunxia Lv (ORCID: https://orcid.org/0000-0003-1359-3514)
- Chengfu Cai (ORCID: https://orcid.org/0009-0003-4328-0196)
- Hui Ye (ORCID: https://orcid.org/0000-0001-7080-1442)
- Zilong Chen (ORCID: https://orcid.org/0009-0002-1453-3839)
- Yun Xie
- Haoxi Cai
- Shiqiang Feng
- Junming Wu
- Yuanpei Jin
- Jing Liu (ORCID: https://orcid.org/0009-0008-2772-0418)
Institutions
- Fujian Medical University (CN)
- Central South University (CN)
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Xiamen Chang Gung Hospital (CN)
- Center for Life Sciences (CN)
- Guangxi Academy of Sciences (CN)
- Xiamen Medical College
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fimmu.2024.1445472
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Xiamen Municipal Bureau of Science and Technology
- Natural Science Foundation of Fujian Province