Blocking IL-33 decelerates cartilage degeneration in knee osteoarthritis through mice model
Overall, the results indicate that IL-33 has a therapeutic function in the treatment of knee osteoarthritis and may be a novel target for treatment of the underlying causes of KOA. Additionally, PDGF-BB might be an upstream pathway of IL-33, and KOA's MMP-9 is an downstream pathway of IL-33.
Authors
- Rujie Zhuang (ORCID: https://orcid.org/0000-0002-2897-2800)
- Siyuan Zhang (ORCID: https://orcid.org/0000-0001-5134-3044)
- Kangxiang Zhu (ORCID: https://orcid.org/0009-0000-6650-0620)
- Fan Wu (ORCID: https://orcid.org/0009-0000-6015-8158)
- Chuanxiao Hu
Institutions
- Zhejiang Chinese Medical University (CN)
- Quzhou City People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1371/journal.pone.0301199
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Zhejiang University