The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity
In general l-LV acts similar to the dl-LV formulations, however disparate effects were observed when d-LV and l-LV were used in combination, conceivably by d-LV affecting (anti)folate transport and intracellular metabolism.
Authors
- Gerrit Jansen (ORCID: https://orcid.org/0000-0001-8190-8368)
- Yehuda G. Assaraf (ORCID: https://orcid.org/0000-0001-6692-8221)
- Ietje Kathmann
- Godefridus J. Peters (ORCID: https://orcid.org/0000-0002-5447-2877)
- Elisa Giovannetti (ORCID: https://orcid.org/0000-0002-7565-7504)
- Kees Smid
Institutions
- Technion – Israel Institute of Technology (IL)
- Fondazione Pisa (IT)
- Amsterdam University Medical Centers (NL)
- Gdańsk Medical University (PL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fphar.2024.1450418
- Citations
- 3
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Spectrum Pharmaceuticals