Histopathologic, genomic, transcriptomic, and functional characteristics of eight melanocytic tumors with <i>BRAF</i> fusions showing stronger MAPK pathway activation compared to <i>BRAF V600E</i> tumors
The quantitatively stronger activation of the MAPK pathway of BRAF fusion tumors, instead of qualitatively different transcriptomes, may account for the morphology difference from conventional BRAF V600E tumors. BRAF fusions likely act through dysregulated protein function rather than RNA upregulation related to the characteristics of the fusion partners.
Authors
- Simon Warren (ORCID: https://orcid.org/0000-0001-6857-6303)
- Aofei Li (ORCID: https://orcid.org/0009-0009-1345-2499)
- Ahmed Al‐Omari (ORCID: https://orcid.org/0000-0002-3776-5053)
- Brandon Umphress
Institutions
- Indiana University Health (US)
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Journal of Cutaneous Pathology
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1111/cup.14704
- Citations
- 2
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.47