Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions
Our findings highlight proteome changes in chronic inactive MS white matter lesions and periplaque white matter, which may be crucial for proper myelinogenesis, bioenergetics, focal adhesions, and cellular function. This study highlights the importance and feasibility of spatial approaches such as laser capture microdissection-based proteomics analysis of pathologically distinct regions of MS brain tissue. Identification of spatially resolved changes in the proteome of MS brain tissue should aid in the understanding of pathophysiological mechanisms and the development of novel therapies.
Authors
- Kiran Kumar Mangalaparthi (ORCID: https://orcid.org/0000-0002-5791-727X)
- Akhilesh Pandey (ORCID: https://orcid.org/0000-0001-9943-6127)
- Jordan Wilkins
- Claudia F. Lucchinetti (ORCID: https://orcid.org/0000-0001-5070-1196)
- Alicja Kalinowska-Lyszczarz
- Yong Guo (ORCID: https://orcid.org/0000-0001-6485-7925)
- Brian C. Netzel
- William A. Sherman
Institutions
- Poznan University of Medical Sciences (PL)
- University of Minnesota (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fnmol.2024.1448215
- Citations
- 5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.12