The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU
The excessive formation of NETs may have important research value in the development and progression of critical illness. Ondansetron may reduce excessive inflammatory injury in critical diseases by reducing the formation of NETs via influencing the five targets: <i>TLR8, NFKB1, MAPK14, NE, and MPO</i>. Ondansetron and these primary predictive biotargets may potentially be used to treat critical illness in future clinical practice.
Authors
- Lili Tao (ORCID: https://orcid.org/0000-0002-9682-3911)
- Minxuan Huang (ORCID: https://orcid.org/0000-0001-5551-586X)
- Chuang Li (ORCID: https://orcid.org/0000-0003-3595-8692)
- Zhenhui Zhang
- Ping Chang (ORCID: https://orcid.org/0009-0008-4455-364X)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fphar.2024.1443169
- Citations
- 4
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province