Benzimidazole‐Containing Compounds as Anticancer Agents
Abstract Cancer is the second leading cause of death today and remains a threat to human health. The advent of multi‐drug resistance and adverse effects make the current first‐line anti‐cancer medicines inadequate, despite the fact that numerous efforts have been made in the field of cancer therapy and significant progress has been made in the diagnosis and treatment of cancer. Consequently, the development of novel anticancer drugs with high activity and minimal toxicity is imperative. The benzimidazole ring has attracted the attention of medicinal chemists due to its medicinal and pharmacological properties. The heterocyclic pharmacophore of benzimidazole is a crucial scaffold for developing pharmaceuticals and drugs. In this review, we summarized the recent progress of benzimidazole as a privileged scaffold for the discovery of anti‐cancer agents based on biological targets, such as VEGFR (Vascular Endothelial Growth Factor), PI3 K inhibitors (Phosphoinositide 3‐kinase), EGFR kinase inhibitors (Epidermal Growth Factor Receptor), PARPs (Poly ADP‐ribose polymerases), Tubulin Polymerization, HAT/HDAC (histone acetylase/histone deacetylase), SphK1 (Sphingosine kinase‐1 inhibitors), aromatase, carbonic anhydrase, and topoisomerase inhibitors. The last 5 years of literature have been reviewed and relevant studies have been summarized in this review.
Authors
- Asaf Evrim Evren (ORCID: https://orcid.org/0000-0002-8651-826X)
- Ravikumar Kapavarapu (ORCID: https://orcid.org/0000-0002-6466-8005)
- İsmail Çeli̇k (ORCID: https://orcid.org/0000-0002-8146-1663)
- Mithun Rudrapal (ORCID: https://orcid.org/0000-0002-8172-6633)
- Ulviye Acar Çevik (ORCID: https://orcid.org/0000-0003-1879-1034)
- Ayşen Işık (ORCID: https://orcid.org/0000-0002-1280-0019)
- Zafer Asım Kaplancıklı (ORCID: https://orcid.org/0000-0003-2252-0923)
- Hakan Ünver (ORCID: https://orcid.org/0000-0002-4858-4039)
- Betül Kaya (ORCID: https://orcid.org/0000-0002-1713-9485)
- Yusuf Özkay (ORCID: https://orcid.org/0000-0001-5948-1855)
- A. Karakaya (ORCID: https://orcid.org/0009-0003-9619-6705)
- Gresa Halimi (ORCID: https://orcid.org/0000-0002-0635-0664)
- Maryam Zahra (ORCID: https://orcid.org/0000-0003-4233-727X)
- Merve Yıldırım (ORCID: https://orcid.org/0000-0001-6834-3470)
- Emine Rana Bağcı (ORCID: https://orcid.org/0009-0004-7452-0532)
Institutions
- Anadolu University (TR)
- Selçuk University (TR)
- Vignan's Foundation for Science, Technology & Research (IN)
- Bilecik Şeyh Edebali Üniversitesi (TR)
- Zonguldak Bülent Ecevit University (TR)
- Eskişehir City Hospital (TR)
- Eskisehir Technical University (TR)
- Nirma (India) (IN)
- Hindu College of Pharmacy (IN)
- Afyonkarahisar Sağlık Bilimleri Üniversitesi
- Afyon Kocatepe University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1002/slct.202401566
- Citations
- 9
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 2.25