Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis
This study suggests that hirudin can improve early-stage diabetic kidney disease kidney damage by inhibiting the migration and angiogenesis of glomerular endothelial cells, thereby further expanding the application scope of hirudin. Additionally, the study found increased expression of AQP1 in DKD, providing a new perspective for further research on the potential pathogenesis of DKD.
Authors
- Xiaolin Tong (ORCID: https://orcid.org/0000-0002-9873-4154)
- Jie Su (ORCID: https://orcid.org/0000-0002-2612-6475)
- Linhua Zhao (ORCID: https://orcid.org/0000-0002-0362-7365)
- Xiaoying Yu
- Fengyi Zhang (ORCID: https://orcid.org/0000-0002-0960-9766)
- Yifeng Zhao (ORCID: https://orcid.org/0009-0000-1985-6835)
- Yujie Li (ORCID: https://orcid.org/0000-0001-8513-8428)
- Wenbo Wang (ORCID: https://orcid.org/0000-0002-2982-4199)
- Xuemei Liu (ORCID: https://orcid.org/0000-0002-2882-5798)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0001-8236-1878)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-1625-7877)
- J. Zhang (ORCID: https://orcid.org/0009-0009-4119-3922)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guang’anmen Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1016/j.biopha.2024.117300
- Citations
- 6
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.73