Effect of β-sitosterol on PEL and PSL of Pseudomonas aeruginosa

Pseudomonas aeruginosa is one of the major reasons of nosocomial infections and well known of its high morbidity and mortality in hospitals. Additionally, it is well known of its intrinsic resistance to most of antibiotics. P. aeruginosa virulence factors have been investigated well in recent years and it has been classified according to their secreted factors for attachment into alginate, PEL, PSL. In this study we investigated reduction effect of β- sitosterol which is a natural compound found in most of plants, on biofilm formed by different biofilm-associated mutant strains and wild types of P. aeruginosa. The results revealed that β- sitosteral has antibacterial and showing reduction in biofilm formation on P. aeruginosa. Also, β- sitosterol significantly affects swarming and swimming of most strains.