Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community‐based study
The PRS<sub>APOE</sub> and PRS<sub>non-</sub> <sub>APOE</sub> were associated with AD risk in the Chinese population. The PRS<sub>APOE</sub> and PRS<sub>non-</sub> <sub>APOE</sub>, in combination with demographics, showed good discriminative and predictive ability for AD. The AD-related pathologies underlie the AD risk associated with PRS<sub>APOE</sub> but not PRS<sub>non-</sub> <sub>APOE</sub>.
Authors
- Yifei Ren (ORCID: https://orcid.org/0000-0002-6081-7392)
- Shan Xu (ORCID: https://orcid.org/0000-0002-0679-0897)
- Yifeng Du (ORCID: https://orcid.org/0000-0002-4672-6654)
- Xiaoyan Liang
- Chengxuan Qiu (ORCID: https://orcid.org/0000-0003-1922-4912)
- Min Zhu (ORCID: https://orcid.org/0000-0002-7468-0083)
- Wenxin Fa (ORCID: https://orcid.org/0000-0001-5521-9163)
- Lin Cong
- Xiang Wang (ORCID: https://orcid.org/0000-0003-3452-7911)
- Yongxiang Wang (ORCID: https://orcid.org/0000-0002-8832-7301)
- Cuicui Liu
- Keke Liu (ORCID: https://orcid.org/0000-0003-2222-5940)
- Shi Tang
- Tingting Hou (ORCID: https://orcid.org/0000-0003-2614-8145)
- Qihuan Tan
Institutions
- Shandong University (CN)
- Stockholm University (SE)
- University of Southern Denmark (DK)
- Karolinska Institutet (SE)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1002/alz.13924
- Citations
- 8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- Swedish Foundation for International Cooperation in Research and Higher Education
- National Natural Science Foundation of China
- Vetenskapsrådet
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Natural Science Foundation of Shandong Province
- Shandong First Medical University
- Postdoctoral Innovation Project of Shandong Province