Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, <i>EGFR</i> –Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer
Addition of pembrolizumab to chemotherapy in patients with TKI-resistant, <i>EGFR</i>-mutant, metastatic nonsquamous NSCLC did not significantly prolong PFS or OS versus placebo plus chemotherapy in KEYNOTE-789.
Authors
- Phillip Parente (ORCID: https://orcid.org/0000-0003-0096-7601)
- Fernanda Maris Peria (ORCID: https://orcid.org/0000-0001-5133-165X)
- Silvia Novello (ORCID: https://orcid.org/0000-0001-7653-9748)
- Filippo de Marinis (ORCID: https://orcid.org/0000-0002-1118-5536)
- Jair Bar (ORCID: https://orcid.org/0000-0002-1224-3646)
- Rina Hui (ORCID: https://orcid.org/0000-0003-0696-7442)
- Shun Lü (ORCID: https://orcid.org/0000-0001-8833-7262)
- Rachel E. Sanborn (ORCID: https://orcid.org/0000-0003-0542-6054)
- Ki Hyeong Lee (ORCID: https://orcid.org/0000-0002-7830-5950)
- Pedro Rafael Martins De Marchi
- David Vicente (ORCID: https://orcid.org/0000-0002-6052-0070)
- Yuichi Tambo (ORCID: https://orcid.org/0000-0002-4095-4533)
- Natasha B. Leighl (ORCID: https://orcid.org/0000-0002-3249-4602)
- Masashi Kondo (ORCID: https://orcid.org/0000-0001-8818-8316)
- Toshiaki Takahashi (ORCID: https://orcid.org/0000-0002-8188-2505)
- Sivan Shamai
- Kazuo Kasahara (ORCID: https://orcid.org/0000-0001-5551-1543)
- Takako Inoue (ORCID: https://orcid.org/0009-0002-8698-0590)
- Nagashree Seetharamu (ORCID: https://orcid.org/0000-0002-3282-7622)
- Jin Hyoung Kang (ORCID: https://orcid.org/0000-0002-3741-5168)
- Sandeep H. Mashru
- Domenico Galetta (ORCID: https://orcid.org/0000-0002-4878-5906)
- Kazuma Kishi (ORCID: https://orcid.org/0000-0002-6801-0147)
- Francesca Mazzoni (ORCID: https://orcid.org/0000-0002-5828-7839)
- Ji‐Youn Han (ORCID: https://orcid.org/0000-0001-5033-0006)
- Helong Zhang (ORCID: https://orcid.org/0000-0001-8430-6071)
- Francesco Di Costanzo (ORCID: https://orcid.org/0000-0002-6858-7827)
- Kam Zaki
- Dae Ho Lee (ORCID: https://orcid.org/0000-0002-9749-4638)
- Daniel C. Christoph (ORCID: https://orcid.org/0000-0002-3151-6427)
- Andrew Mant (ORCID: https://orcid.org/0000-0002-1821-6374)
- R. Öhman
- Qiming Wang (ORCID: https://orcid.org/0000-0002-7813-2885)
- Manuel Cobo (ORCID: https://orcid.org/0000-0003-3402-1144)
- Bruno Coudert (ORCID: https://orcid.org/0000-0001-9445-2216)
- Wu‐Chou Su (ORCID: https://orcid.org/0000-0003-2953-4105)
- Yoshitsugu Horio (ORCID: https://orcid.org/0000-0003-4661-6399)
- Julien Dutilh
- Keunchil Park (ORCID: https://orcid.org/0000-0002-4846-7449)
- Cheng‐Ta Yang (ORCID: https://orcid.org/0000-0003-1846-1027)
- Martin Wermke (ORCID: https://orcid.org/0000-0002-4844-4087)
- Hiroshige Yoshioka (ORCID: https://orcid.org/0000-0001-7724-0481)
- Janakiraman Subramanian (ORCID: https://orcid.org/0000-0003-0083-9896)
- Chun‐Yao Huang (ORCID: https://orcid.org/0000-0002-8978-7879)
- Hans‐Georg Kopp (ORCID: https://orcid.org/0000-0002-0825-8888)
- Yu Yao (ORCID: https://orcid.org/0000-0002-8366-4712)
- Jason Agulnik
- Emmanuel de la Mora Jimenez
- Noam Asna (ORCID: https://orcid.org/0009-0007-1720-069X)
- Thomas Newsom-Davis (ORCID: https://orcid.org/0000-0001-9317-3434)
- Leandro Brust
- Maya Gottfried
- Laura Doni
- Rainer Wiewrodt
- Sing Hung Lo
- Dan Costin
- Gongyan Chen
- Jonathan Shamash
- M. Pérol
- Hiroaki Takeoka (ORCID: https://orcid.org/0000-0003-0296-3698)
- Eiji Iwama (ORCID: https://orcid.org/0000-0001-8252-290X)
- Bengt Bergman
- Luis Paz-Ares Rodríguez
- Francesco Ferraù (ORCID: https://orcid.org/0000-0002-7472-6598)
- Julien Dômont (ORCID: https://orcid.org/0009-0008-1214-1835)
- Eiki Ichihara (ORCID: https://orcid.org/0000-0002-2966-106X)
- Pilar Garrido (ORCID: https://orcid.org/0000-0002-5899-6125)
- Dionysis Papadatos-Pastos
- Youssef Oulkhouir
- Jianying Zhou (ORCID: https://orcid.org/0000-0002-8924-935X)
- Jih‐Hsiang Lee
- Kiyotaka Yoh (ORCID: https://orcid.org/0000-0001-6928-357X)
- Frank Griesinger (ORCID: https://orcid.org/0000-0002-6822-5498)
- Yukio Hosomi (ORCID: https://orcid.org/0000-0002-3849-5905)
- James Chih‐Hsin Yang (ORCID: https://orcid.org/0000-0002-5586-5138)
- Annette Mueller
- Masao Ichiki
- Keisuke Kirita (ORCID: https://orcid.org/0000-0003-4998-1826)
- Parneet Kaur Cheema (ORCID: https://orcid.org/0000-0002-9680-7073)
- Stanislas Ropert
- Margarita Majem (ORCID: https://orcid.org/0000-0002-9919-7485)
- Giuseppe Tonini (ORCID: https://orcid.org/0000-0003-4442-8677)
- Jens Kern (ORCID: https://orcid.org/0009-0009-3245-385X)
- Gregory J. Riely (ORCID: https://orcid.org/0000-0001-5357-4313)
- Sérgio Jobim Azevedo (ORCID: https://orcid.org/0000-0002-9230-4284)
- Alona Zer (ORCID: https://orcid.org/0000-0001-6597-5261)
- Shunsuke Teraoka (ORCID: https://orcid.org/0000-0003-2444-5744)
- Takayasu Kurata (ORCID: https://orcid.org/0000-0003-4123-3567)
- Se‐Hoon Lee (ORCID: https://orcid.org/0000-0002-9219-3350)
- Jerónimo Rafael Rodríguez Cid
- Kejing Ying (ORCID: https://orcid.org/0000-0001-9642-3929)
- Ian Anderson (ORCID: https://orcid.org/0000-0003-2205-9209)
- M. Catherine Pietanza (ORCID: https://orcid.org/0000-0002-5663-661X)
- Chao‐Hua Chiu (ORCID: https://orcid.org/0000-0001-8401-2356)
- Daiya Takai
- Fábio Franke (ORCID: https://orcid.org/0000-0002-9417-2123)
- Isamu Okamoto (ORCID: https://orcid.org/0000-0002-7587-6096)
- Jerónimo Rafael Rodríguez‐Cid (ORCID: https://orcid.org/0000-0001-8518-9065)
- Richard D. Hall (ORCID: https://orcid.org/0000-0001-5812-8857)
- Gee‐Chen Chang (ORCID: https://orcid.org/0000-0002-1802-417X)
- Anders Vikström (ORCID: https://orcid.org/0000-0003-3549-3944)
- Te‐Chun Hsia (ORCID: https://orcid.org/0000-0003-4297-9918)
- Melanie Mackean (ORCID: https://orcid.org/0000-0002-3728-5746)
- Toshiyuki Kozuki (ORCID: https://orcid.org/0000-0001-8432-8975)
- Diana Chirovsky (ORCID: https://orcid.org/0000-0003-1641-1990)
- Michael Boyer (ORCID: https://orcid.org/0000-0002-0452-2987)
- Donald B. Wender
- Julia Dudnik
- Fabiana Vitiello (ORCID: https://orcid.org/0009-0007-2984-4257)
- Gustavo Werutsky (ORCID: https://orcid.org/0000-0001-6271-105X)
- Francovito Piantedosi
- Ambika Parmar
- Ronald B. Natale
- Chung Man James Ho
- Viola W. Zhu (ORCID: https://orcid.org/0000-0002-9313-3253)
- Dominique Spaeth
- Gilberto de Castro (ORCID: https://orcid.org/0000-0001-8765-3044)
- Toyoaki Hida (ORCID: https://orcid.org/0000-0003-3537-0020)
- Lin Wu (ORCID: https://orcid.org/0000-0001-7078-7767)
- Makenzi Colleen Evangelist
- Sagun Parakh (ORCID: https://orcid.org/0000-0003-3891-2489)
- Sai‐Hong Ignatius Ou (ORCID: https://orcid.org/0000-0002-1764-4975)
- Claas Wesseler (ORCID: https://orcid.org/0000-0002-9261-7504)
- Ines B. Menjak (ORCID: https://orcid.org/0000-0002-4239-0858)
- Thomas John (ORCID: https://orcid.org/0000-0003-3399-5342)
- Mark Doherty
- D. Carmier
- Xiangdong Zhou (ORCID: https://orcid.org/0000-0002-4451-5327)
- Hisashi Takaya
- Yuichiro Ohe (ORCID: https://orcid.org/0000-0002-6137-073X)
- Terufumi Kato (ORCID: https://orcid.org/0000-0002-5853-1424)
- Enric Carcereny (ORCID: https://orcid.org/0000-0001-5235-5602)
- Jonathan E. Dowell (ORCID: https://orcid.org/0000-0002-0202-9697)
- Chin-Chou Wang
- Li Zhang (ORCID: https://orcid.org/0000-0002-7000-2955)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-4241-5613)
- Saad A. Khan (ORCID: https://orcid.org/0000-0002-3440-9774)
- Jong‐Seok Lee (ORCID: https://orcid.org/0000-0001-5255-4425)
- Cheng Zhi Huang (ORCID: https://orcid.org/0000-0002-1260-5934)
- Yun Fan (ORCID: https://orcid.org/0000-0003-1355-7513)
- Ji‐Feng Feng (ORCID: https://orcid.org/0000-0002-6983-1318)
- Victor Lee (ORCID: https://orcid.org/0000-0002-6283-978X)
- Ahmad Raza (ORCID: https://orcid.org/0000-0003-4496-0751)
- Yoshihiro Hattori
- Pooja Jain (ORCID: https://orcid.org/0000-0002-6595-8194)
- Ying Cheng (ORCID: https://orcid.org/0000-0002-4102-2578)
- Zhigang Han (ORCID: https://orcid.org/0000-0002-9993-3382)
- Hiroshi Tanaka (ORCID: https://orcid.org/0000-0002-8003-7326)
- Hideo Saka (ORCID: https://orcid.org/0000-0001-7364-5115)
- Ziping Wang
- Toru Kumagai (ORCID: https://orcid.org/0000-0002-1232-0015)
- Jianying Zhou
- Yingying Du (ORCID: https://orcid.org/0000-0002-5149-4632)
- Tsung‐Ying Yang
- Yiwen Luo (ORCID: https://orcid.org/0000-0002-5187-6841)
- Shobhit Baijal (ORCID: https://orcid.org/0000-0002-5842-6886)
- Virginie Westeel (ORCID: https://orcid.org/0000-0003-2358-3694)
- Jiuwei Cui
- E. Felip Font
- Smitha Menon
- Corinne Lamour
- Hsu-Ching Huang
- Jian Su (ORCID: https://orcid.org/0000-0002-1425-025X)
- Kang‐Yun Lee
- Simon Ekman
- C.A. Hernández (ORCID: https://orcid.org/0009-0001-3366-196X)
- Laura Stampleman
- Niyati Bhagwati
- Joilda Batista De Almeida Rego
- Dong‐Wan Kim
- Chengping Hu
- G Vogel
- Aurélie Lagrange
- Eun Kyung Cho
- Young Joo Min
- Sheng-Hao Lin
- Chih-Bin Lin
- Gustavo Dix Junqueira
- Mark E. Wong
- Mirjana Wollner
- Nicholas Campbell (ORCID: https://orcid.org/0009-0007-0358-1647)
- Shang-Yin Wu
- Stephan DiSean Kendall
- Ofer Rotem
- David Vicente Baz (ORCID: https://orcid.org/0000-0002-6832-9705)
- Mhameed Kamel
- Shi Feng Jonathan Nyaw
- Yu Chung Jacky Li
- Juliet Brock
- Samreen Ahmed
- Óscar Gerardo Arrieta Rodríguez
- Mor Moskovitz
- Siu Hong Oscar Chan
- Masahide Oki
- Yan Wang (ORCID: https://orcid.org/0009-0002-3286-3516)
- Yong Zhang (ORCID: https://orcid.org/0009-0009-7948-512X)
Institutions
- Ulsan College (KR)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Memorial Sloan Kettering Cancer Center (US)
- Kyushu University (JP)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Asan Medical Center (KR)
- Shanghai Chest Hospital (CN)
- Seoul National University Bundang Hospital (KR)
- University of Ulsan (KR)
- Hospital Universitario Virgen Macarena (ES)
- Taoyuan Chang Gung Memorial Hospital (TW)
- Zhejiang Cancer Hospital (CN)
- Okayama University Hospital (JP)
- Hospital Médica Sur (MX)
- Centre Léon Bérard (FR)
- Istituto Oncologico Veneto (IT)
- National Taiwan University Hospital (TW)
- Instituto Jalisciense de Cancerología (MX)
- Osaka International Cancer Institute (JP)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Chungbuk National University Hospital (KR)
- First Affiliated Hospital Zhejiang University (CN)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1200/jco.23.02747
- Citations
- 126
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 50.27
Funders
- Eli Lilly and Company