PM2.5 exposure and household income are associated with lung function abnormalities in children with sickle cell disease
We report higher odds of obstruction in pwSCD frequently exposed to PM2.5 concentrations above 25 μg/m<sup>3</sup> and higher odds of restriction in pwSCD with lower household income. Our findings link spirometry patterns to modifiable risk factors indicating that there may opportunities for early intervention in pwSCD that have been referred to a pulmonology clinic. Further research is needed to assess if these findings can be generalized to the wider population of pwSCD.
Authors
- Julian Lewis Allen (ORCID: https://orcid.org/0000-0003-0949-0010)
- Jelte Kelchtermans (ORCID: https://orcid.org/0000-0001-9186-7547)
- Anita Bhandari (ORCID: https://orcid.org/0000-0002-4134-8885)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1002/ppul.27222
- Citations
- 2
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Children's Hospital of Philadelphia
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Environmental Health Sciences