PD-1 mediates microglia polarization via the MAPK signaling pathway to protect blood-brain barrier function during cerebral ischemia/reperfusion
Our present study verified that PD-1 exerts an anti-inflammatory effect by converting the microglia M1 phenotype to the M2 phenotype, reducing BBB permeability, and thereby relieves brain injury caused by cerebral ischemia. PD-1 is potential therapeutic target for brain injury caused by cerebral ischemia.
Authors
- Juhao Zeng
- Hongke Zeng (ORCID: https://orcid.org/0000-0003-3243-4199)
- Huishan Zhu
- Xinping Li (ORCID: https://orcid.org/0000-0003-2033-1248)
- Zhuo Li (ORCID: https://orcid.org/0000-0002-1019-3809)
- Linqiang Huang
- Yongli Han (ORCID: https://orcid.org/0000-0001-9673-9181)
- Miaoyun Wen (ORCID: https://orcid.org/0000-0003-4385-8990)
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111055
- Citations
- 9
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.23