Adipose‐derived stem cells transplantation improves survival and alleviates contraction of skin grafts via promoting macrophages M2 polarization
ASCs treatment enhanced vascularization via angiogenic cytokines secretion and alleviated inflammatory environment in skin grafts by driving M2 macrophages polarization, which improved survival and decreased skin grafts contraction. Our work showed that ASCs transplantation can be harnessed to enhance therapeutic efficacy of skin grafting in cutaneous defects treatment.
Authors
- Guangshuai Li
- Zheyuan Yu (ORCID: https://orcid.org/0009-0004-4476-7147)
- Dejun Cao (ORCID: https://orcid.org/0000-0002-7078-8636)
- Sizheng Zhou (ORCID: https://orcid.org/0009-0007-5490-256X)
- Taoran Jiang (ORCID: https://orcid.org/0000-0003-3649-0470)
- Yuying Cui (ORCID: https://orcid.org/0009-0002-0517-9479)
- Jiahao He (ORCID: https://orcid.org/0009-0001-7642-637X)
- Bin Fang (ORCID: https://orcid.org/0000-0002-9242-5895)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Skin Research and Technology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/srt.13918
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- Shanghai Clinical Research Center
- School of Medicine, Shanghai Jiao Tong University