Protein Aggregation on Metal Oxides Governs Catalytic Activity and Cellular Uptake (Small 34/2024)
Catalytically Active Nanomaterials Catalytically active nanomaterials offer significant potential for biomedical applications, including enhancing wound healing and inducing cancer cell death. In article number 2311115, Robert Nißler, Inge K. Herrmann, and co-workers demonstrate that protein corona formation reduces the catalytic efficacy of metal oxides and promotes their uptake by tissue-resident macrophages. Nonetheless, endosomal conditions partially restore the nanocatalytic activity and enable access to bioactivity.
Authors
- Anna L. Neuer (ORCID: https://orcid.org/0000-0002-5762-4709)
- Inge Katrin Herrmann (ORCID: https://orcid.org/0000-0002-3018-6796)
- Ioana Leşe (ORCID: https://orcid.org/0000-0002-3007-097X)
- Simone de Brot (ORCID: https://orcid.org/0000-0003-3049-0103)
- Martin T. Matter (ORCID: https://orcid.org/0000-0003-0748-1508)
- Robert Nißler
- Vera M. Kissling (ORCID: https://orcid.org/0000-0002-4524-9905)
- Alexander Gogos (ORCID: https://orcid.org/0000-0001-6233-512X)
- Lukas R. H. Gerken (ORCID: https://orcid.org/0000-0002-8568-2674)
- Lena Dennebouy
- Maximilian Dommke
- Monika Zimmermann
- Michael A. Pais
Institutions
- University of Bern (CH)
- University of Zurich (CH)
- University Hospital of Bern (CH)
- ETH Zurich (CH)
- Universitätsklinik Balgrist (CH)
- Swiss Federal Laboratories for Materials Science and Technology (CH)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Small
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/smll.202470258
- Primary Topic
- Biological Research and Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00