Fecal Proteolytic Bacteria and Staphylococcal Superantigens Are Associated With Abdominal Pain Severity in Irritable Bowel Syndrome
In keeping with our preclinical findings, we show that increased presence of SAg-producing S. aureus in fecal samples of patients with IBS is associated with increased levels of abdominal pain. We also show that increased fecal proteolytic activity is associated with increased abdominal pain in patients with IBS.
Authors
- Javier Aguilera‐Lizarraga (ORCID: https://orcid.org/0000-0002-8135-9933)
- María Cuende‐Estévez (ORCID: https://orcid.org/0000-0002-4094-3287)
- Hind Hussein (ORCID: https://orcid.org/0000-0001-6309-8242)
- Lisse Decraecker (ORCID: https://orcid.org/0000-0002-5366-1262)
- Jill Wykosky
- Runze Quan (ORCID: https://orcid.org/0000-0002-7536-4939)
- Guy E. Boeckxstaens (ORCID: https://orcid.org/0000-0001-8267-5797)
- Peter McLean (ORCID: https://orcid.org/0000-0001-7938-5713)
- Alexandre Denadai‐Souza (ORCID: https://orcid.org/0000-0003-0385-1321)
- Gareth A. Hicks (ORCID: https://orcid.org/0000-0001-5106-757X)
- Samuel Van Remoortel (ORCID: https://orcid.org/0000-0001-8425-5657)
- Iris Appeltans
- Zheng Wang
Institutions
- University of Cambridge (GB)
- Bridge University (SS)
- Fate Therapeutics (United States) (US)
- KU Leuven (BE)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.14309/ajg.0000000000003042
- Citations
- 9
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Fonds Wetenschappelijk Onderzoek
- Onderzoeksraad, KU Leuven