Shifts in Serum Bile Acid Profiles Associated With Barrett's Esophagus and Stages of Progression to Esophageal Adenocarcinoma
Alterations in serum bile acids are independently associated with advanced neoplasia in BE and may contribute to neoplastic progression. Future studies should explore associated gut microbiome changes, proneoplastic effects of bile acids, and whether these bile acids, particularly cholic acid, represent potential biomarkers or viable therapeutic targets for advanced neoplasia in BE.
Authors
- Kenneth K. Wang (ORCID: https://orcid.org/0000-0002-2156-6164)
- Prasad G. Iyer (ORCID: https://orcid.org/0000-0002-9822-1420)
- Charles J. Lightdale (ORCID: https://orcid.org/0000-0002-3320-2923)
- Harris H. Wang (ORCID: https://orcid.org/0000-0003-2164-4318)
- Jeanine M. Genkinger (ORCID: https://orcid.org/0000-0002-8438-0412)
- Stephen M. Lagana
- Michael Quante (ORCID: https://orcid.org/0000-0002-8497-582X)
- Aarti Kumar (ORCID: https://orcid.org/0000-0003-4331-3747)
- Zhezhen Jin (ORCID: https://orcid.org/0000-0002-3801-0680)
- Armando Del Portillo (ORCID: https://orcid.org/0000-0002-8507-8450)
- Gary W. Falk (ORCID: https://orcid.org/0000-0002-7143-1436)
- Julian A. Abrams (ORCID: https://orcid.org/0000-0002-6021-9376)
- Gregory G. Ginsberg (ORCID: https://orcid.org/0000-0002-2023-7422)
- Hongzhe Li (ORCID: https://orcid.org/0000-0003-3662-3907)
- Pranav Gwalani
- Yun Li (ORCID: https://orcid.org/0000-0001-8414-2724)
- Timothy C. Wang (ORCID: https://orcid.org/0000-0001-5730-3019)
- Anil K. Rustgi (ORCID: https://orcid.org/0000-0002-5877-7993)
Institutions
- Mayo Clinic (US)
- University of Freiburg (DE)
- Columbia University Irving Medical Center (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.14309/ctg.0000000000000762
- Citations
- 5
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.86