Double Direct C–H Bond Arylation of Thiophenes with Aryl Chlorides Catalyzed by the <i>N</i>-Heterocyclic Carbene-PdCl<sub>2</sub>-1-methylimidazole Complex
With the combination of the <i>N</i>-heterocyclic carbene-PdCl<sub>2</sub>-1-methylimidazole complex and Cu<sub>2</sub>O, we succeeded in the first example of double direct C-H bond arylation reactions between thiophenes and aryl chlorides, giving the desired 2,5-diarylated thiophenes in moderate to high yields under suitable conditions, consistent with the density functional theory calculations.
Authors
- Li‐Xiong Shao (ORCID: https://orcid.org/0000-0002-7589-1800)
- Xiaoxu Bo (ORCID: https://orcid.org/0009-0008-4491-0731)
- Chao Wang (ORCID: https://orcid.org/0000-0002-9165-7758)
- Yi‐hong Ding (ORCID: https://orcid.org/0000-0001-9598-437X)
- Quan Zhou (ORCID: https://orcid.org/0000-0002-9428-175X)
- Ke-Jiang Liang
Institutions
- Wenzhou University (CN)
- Wenzhou Vocational College of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1021/acs.joc.4c01478
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- Department of Education of Zhejiang Province
- Science and Technology Department of Zhejiang Province