Pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders
A growing body of research has provided evidence that de novo expression of connexin hemichannels and upregulation of pannexin hemichannels (Cx HCs and Panx HCs, respectively) in the cytoplasmic membrane of skeletal muscle (sarcolemma) are critical steps in the pathogenesis of muscle dysfunction of many genetic and acquired muscle diseases. This review provides an overview of the current understanding of the molecular mechanisms regulating the expression of Cx and Panx HCs in skeletal muscle, as well as their roles in both muscle physiology and pathologies. Additionally, it addresses existing gaps in knowledge and outlines future challenges in the field.
Authors
- Juan C. Sáez (ORCID: https://orcid.org/0000-0003-3811-0347)
- Carlos A. Toro (ORCID: https://orcid.org/0000-0002-7355-7534)
- Walter Vásquez (ORCID: https://orcid.org/0000-0003-4113-8172)
- Christopher P. Cardozo (ORCID: https://orcid.org/0000-0003-4013-2537)
- A. Luis
Institutions
- Pontificia Universidad Católica de Chile (CL)
- Universidad Autónoma de Chile (CL)
- James J. Peters VA Medical Center (US)
- University of Valparaíso (CL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- The Journal of Physiology
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1113/jp286173
- Citations
- 4
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- U.S. Department of Defense
- Agencia Nacional de Investigación y Desarrollo
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias