A Modular Three-Component Approach for Site-selective Tandem Arene Thiophosphorylation
Thiophosphates serve as pivotal reagents within the realms of both organic and inorganic synthesis, with their most notable applications observed in agricultural chemistry. This manuscript delineates a modular three-component synthetic strategy for site-selective arene C-H thiophosphorylation with thianthrenium salt, 1,4-diazabicyclo[2.2.2]octane-sulfur dioxide (DABSO), and diarylphosphine oxides as substrates. This approach facilitates the metal-free and green synthesis of a diverse spectrum of <i>S</i>-aryl phosphorothioates through C-H functionalization and late-stage modification showcasing practicality and broad applicability.
Authors
- Li‐Fang Wang (ORCID: https://orcid.org/0000-0003-1593-4482)
- Ziyu Gan (ORCID: https://orcid.org/0009-0005-0226-0572)
- Yongqiang Zhang (ORCID: https://orcid.org/0000-0003-1403-9128)
- Yunhe Jin (ORCID: https://orcid.org/0000-0003-0626-4587)
- Shuyang Liu
- Ziyang Chen (ORCID: https://orcid.org/0000-0002-2467-8372)
- Yihao Li (ORCID: https://orcid.org/0000-0002-5271-1395)
- Jia‐Jin Jason Chen (ORCID: https://orcid.org/0000-0003-2751-5066)
- Han Wang (ORCID: https://orcid.org/0009-0008-1462-649X)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1021/acs.orglett.4c02525
- Citations
- 6
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Dalian University of Technology
- Fundamental Research Funds for the Central Universities