CuSO<sub>4</sub>/<i>N</i>-(9<i>H</i>-carbazol-9-yl)picolinamide-Catalyzed C–O Coupling of (Hetero)Aryl Chlorides with Phenols on Water
A Cu-catalyzed C-O coupling of (hetero)aryl chlorides with phenols at 120 °C on water was developed with a designed ligand, <i>N</i>-(9<i>H</i>-carbazol-9-yl)picolinamide (<b>L2</b>). This method features a good substrate scope (both electron-donating and electron-withdrawing), low catalyst/ligand loadings (down to 1 mol %), and excellent scalability and practicability.
Authors
- Yiqian Wan (ORCID: https://orcid.org/0000-0002-9591-9022)
- Manna Huang (ORCID: https://orcid.org/0000-0002-2805-1593)
- Peng Hong
- Fu Chen
- Xinhai Zhu (ORCID: https://orcid.org/0009-0001-8188-0868)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1021/acs.orglett.4c02620
- Citations
- 7
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China