Synthesis of 5-Trifluoromethyl-1,3-thiazin-4-one Compounds using Trifluoromethyl Acrylic Acid as a Synthon

A novel method has been developed for the synthesis of 1,3-thiazin-4-one compounds containing trifluoromethyl groups utilizing 2-trifluoromethyl acrylic acid and thioamides as key starting materials. This protocol is characterized by its simplicity, practicality, and tolerance toward various functional groups. Given the straightforward nature of the procedure, the ready availability of both starting materials, and the significance of drugs containing trifluoromethyl, it is anticipated that this reaction will have wide-ranging applications.