Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials
To our knowledge, this is the first pooled analysis of two randomized trials after direct head-to-head comparison of both TNT sequences. Both trials reported higher rates of complete response with CRT-CNCT, and this should be considered the preferred TNT sequence if organ preservation is a priority.
Authors
- Michael B. Ghadimi (ORCID: https://orcid.org/0000-0001-8208-1526)
- Li‐Xuan Qin (ORCID: https://orcid.org/0000-0002-9367-3807)
- Robert Grützmann (ORCID: https://orcid.org/0000-0003-2559-0476)
- Julio García‐Aguilar (ORCID: https://orcid.org/0000-0003-2451-0948)
- Martin R. Weiser (ORCID: https://orcid.org/0000-0002-9577-7984)
- Claus Rödel
- Pompiliu Piso (ORCID: https://orcid.org/0000-0001-7146-4505)
- Abraham J. Wu (ORCID: https://orcid.org/0000-0002-2597-7091)
- Emmanouil Fokas (ORCID: https://orcid.org/0000-0003-1601-6165)
- Hendrik Dapper
- Leonard B. Saltz (ORCID: https://orcid.org/0000-0001-8353-4670)
- Dana M. Omer (ORCID: https://orcid.org/0000-0002-2259-2540)
- Ralf‐Dieter Hofheinz (ORCID: https://orcid.org/0000-0001-5972-8504)
- J. Joshua Smith (ORCID: https://orcid.org/0000-0003-2538-5456)
- Markus Diefenhardt (ORCID: https://orcid.org/0000-0002-9042-9729)
- Sabrina T. Lin (ORCID: https://orcid.org/0000-0001-7535-2535)
- Hannah Williams (ORCID: https://orcid.org/0000-0001-8928-4190)
- Juán Friede
- Christoph‐Thomas Germer
Institutions
- Goethe University Frankfurt (DE)
- Memorial Sloan Kettering Cancer Center (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Heidelberg University (DE)
- University of Würzburg (DE)
- University Hospital Heidelberg (DE)
- Düsseldorf University Hospital (DE)
- Integrated Oncology (United States) (US)
- Universitätsmedizin Göttingen (DE)
- Krankenhaus Barmherzige Brüder (DE)
- Hackensack Meridian Health (US)
- University Hospital Cologne (DE)
- University Medical Centre Mannheim (DE)
- Frankfurt Cancer Institute (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1016/j.ejca.2024.114291
- Citations
- 17
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.80
Funders
- Deutsche Krebshilfe
- Universität zu Köln
- National Cancer Institute