Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer
The results showed differences in the number of aminoacid residues involved in the interaction of purine and their derivatives with 5uen, 5mzj and 3hng proteins compared with the controls. Besides, the inhibition constants (Ki) values for purine and their derivatives 5: , 9: , 10: , 14: , 15: , 16: , and 20: were lower compared with the controls CONCLUSIONS: Theoretical data suggest that purine and their derivatives 5: , 9: , 10: , 14: , 15: , 16: , and 20: could produce changes in cancer cell growth through inhibition of A<sub>1</sub>, A<sub>2</sub>-adenosine receptors and VEGFR-1 inhibition. These data indicate that these purine derivatives could be a therapeutic alternative to treat some types of cancer.
Authors
- Marcela Rosas (ORCID: https://orcid.org/0000-0002-9442-9638)
- Figueroa‐Valverde Lauro (ORCID: https://orcid.org/0000-0001-8056-9069)
- Virginia Mateu
- E. Hernández Aguilar
- Magdalena Alvarez
- Enrique Bonilla
Institutions
- Universidad Veracruzana (MX)
- Autonomous University of Campeche (MX)
Publication Details
- Journal
- Drug Research
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1055/a-2376-5771
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00