GATA4 downregulation enhances CCL20-mediated immunosuppression in hepatocellular carcinoma
Our study reveals that GATA4 downregulation contributes to an immunosuppressive microenvironment, driven by CCL20-mediated enrichment of regulatory T cells and myeloid-derived suppressor cells in HCC. These findings underscore the critical role of GATA4 reduction in promoting immunosuppression and HCC progression.
Authors
- Alfred Wei Chieh Kow (ORCID: https://orcid.org/0000-0001-8942-8262)
- Alexander Yaw Fui Chung (ORCID: https://orcid.org/0000-0002-4598-6139)
- Joelle Yi Heng Chua
- Rebecca Ba
- John F. Ouyang (ORCID: https://orcid.org/0000-0002-1239-1577)
- Salvatore Albani
- Phuong H. D. Nguyen (ORCID: https://orcid.org/0000-0001-9370-715X)
- Tony Kiat Hon Lim (ORCID: https://orcid.org/0000-0003-0645-5164)
- Han Chong Toh (ORCID: https://orcid.org/0000-0003-0642-3453)
- Yock Young Dan (ORCID: https://orcid.org/0000-0002-7546-2117)
- Sharifah Nur Hazirah (ORCID: https://orcid.org/0000-0003-4636-6430)
- Peng Chung Cheow (ORCID: https://orcid.org/0000-0002-8102-1203)
- Glenn Kunnath Bonney (ORCID: https://orcid.org/0000-0002-9034-3255)
- Weiwei Zhai (ORCID: https://orcid.org/0000-0001-7938-0226)
- Gwyneth Shook Ting Soon (ORCID: https://orcid.org/0000-0001-5318-9327)
- Yin Huei Pang (ORCID: https://orcid.org/0000-0003-0751-0612)
- Mei Chee Lim (ORCID: https://orcid.org/0000-0002-8338-9554)
- Brian K. P. Goh (ORCID: https://orcid.org/0000-0001-8218-4576)
- Timothy Wai Ho Shuen (ORCID: https://orcid.org/0000-0001-9305-7652)
- Pierce K. H. Chow (ORCID: https://orcid.org/0000-0003-0584-2584)
- Samuel Chuah (ORCID: https://orcid.org/0000-0002-7509-5126)
- Chun Jye Lim (ORCID: https://orcid.org/0000-0001-6964-1197)
- Martin Wasser (ORCID: https://orcid.org/0000-0002-8753-2346)
- Tracy Jiezhen Loh (ORCID: https://orcid.org/0000-0002-2590-5784)
- Juinn Huar Kam (ORCID: https://orcid.org/0000-0002-2478-9689)
- Wei Qiang Leow (ORCID: https://orcid.org/0000-0001-6003-9837)
- Shridhar Ganpathi Iyer (ORCID: https://orcid.org/0000-0002-4630-9842)
- Valerie Chew (ORCID: https://orcid.org/0000-0002-5617-0936)
- N. Jannah M. Nasir (ORCID: https://orcid.org/0000-0003-3700-9036)
- Aldo Prawira (ORCID: https://orcid.org/0000-0003-4414-6928)
- Wei Wan (ORCID: https://orcid.org/0000-0001-9462-5615)
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Chinese Academy of Sciences (CN)
- Singapore General Hospital (SG)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- National University Hospital (SG)
- National University Health System (SG)
- Institute of Zoology (CN)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1097/hc9.0000000000000508
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Gilead Sciences
- Duke-NUS Medical School
- National Research Foundation
- National Research Foundation Singapore
- National University Health System
- Medical Research Council
- National Medical Research Council