Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin in Patients with Type 2 Diabetes and Modifiable Cardiovascular Risk F
This trial aims to assess whether combining statins, ezetimibe, and fenofibrate is as effective as, or possibly superior to, statin monotherapy intensification in lowering cardiovascular and microvascular disease risk for patients with T2D. This could propose a novel therapeutic approach for managing dyslipidemia in T2D.
Authors
- Mi Ji Lee (ORCID: https://orcid.org/0000-0003-1364-1969)
- Yoon‐Sok Chung (ORCID: https://orcid.org/0000-0003-0179-4386)
- Soo Kyung Lim (ORCID: https://orcid.org/0000-0002-4137-1671)
- Soo Heon Kwak (ORCID: https://orcid.org/0000-0003-1230-0919)
- Bong Soo (ORCID: https://orcid.org/0000-0003-0542-2854)
- Ji Hee Yu (ORCID: https://orcid.org/0000-0003-1907-2859)
- Tae Nyun Kim (ORCID: https://orcid.org/0000-0001-6568-2469)
- Hee Kyung Kim (ORCID: https://orcid.org/0000-0002-1617-3171)
- Gwanpyo Koh (ORCID: https://orcid.org/0000-0002-6020-2777)
- Heung Yong Jin (ORCID: https://orcid.org/0000-0002-1841-2092)
- Kee‐Ho Song (ORCID: https://orcid.org/0000-0001-9276-6860)
- Sihoon Lee (ORCID: https://orcid.org/0000-0002-9444-5849)
- Il Seong Nam‐Goong (ORCID: https://orcid.org/0000-0002-0492-0467)
- Kyong Hye Joung (ORCID: https://orcid.org/0000-0001-6674-9506)
- Keun‐Gyu Park (ORCID: https://orcid.org/0000-0002-8403-1298)
- Hyeong-Kyu Park
- Seongbin Hong (ORCID: https://orcid.org/0000-0002-8189-395X)
- Soon Hee Lee (ORCID: https://orcid.org/0000-0003-4776-0501)
- Jae‐Han Jeon (ORCID: https://orcid.org/0000-0002-9217-968X)
- Hyun Jeong Jeon (ORCID: https://orcid.org/0000-0003-2841-0688)
- Ohk‐Hyun Ryu (ORCID: https://orcid.org/0000-0003-1118-6886)
- Jaetaek Kim (ORCID: https://orcid.org/0000-0001-5247-0408)
- In‐Kyung Jeong (ORCID: https://orcid.org/0000-0001-7857-546X)
- Choon Hee Chung (ORCID: https://orcid.org/0000-0003-1144-7206)
- Ho‐Chan Cho (ORCID: https://orcid.org/0000-0003-0712-7728)
- Hea Min Yu (ORCID: https://orcid.org/0000-0001-9731-955X)
- Eun‐Gyoung Hong (ORCID: https://orcid.org/0000-0003-3390-5706)
- Jong Heon Park
- Kyu Chang Won (ORCID: https://orcid.org/0000-0001-5945-3395)
- Sin Gon Kim (ORCID: https://orcid.org/0000-0002-7430-3675)
- Jae Myung Yu (ORCID: https://orcid.org/0000-0001-9179-1554)
- Chong Hwa Kim (ORCID: https://orcid.org/0000-0002-4563-7772)
- Hye Jin Yoo (ORCID: https://orcid.org/0000-0003-0600-0266)
- Juneyoung Lee (ORCID: https://orcid.org/0000-0001-8073-9304)
- Ju Hee Lee (ORCID: https://orcid.org/0000-0001-5976-7175)
- Chan Ho Park (ORCID: https://orcid.org/0000-0003-0409-8132)
- Nam Hoon Kim (ORCID: https://orcid.org/0000-0002-9926-1344)
- Yong‐ho Lee (ORCID: https://orcid.org/0000-0002-6219-4942)
- Jae Hyuk Lee (ORCID: https://orcid.org/0000-0003-2429-4085)
- Sang Yong Kim (ORCID: https://orcid.org/0000-0002-3902-622X)
- Sang Soo Kim (ORCID: https://orcid.org/0000-0002-9687-8357)
- Kyoung‐Ah Kim (ORCID: https://orcid.org/0000-0001-5629-830X)
- Won Jun Kim (ORCID: https://orcid.org/0000-0001-7087-1360)
- Chul Woo Ahn
- Suk Chon
- Keun Yong Park
Institutions
- Inje University (KR)
- Chonnam National University (KR)
- Ulsan College (KR)
- Gachon University (KR)
- Seoul National University (KR)
- Hallym University (KR)
- Chosun University (KR)
- Konyang University (KR)
- Inha University (KR)
- Yonsei University (KR)
- Chungnam National University (KR)
- Korea University (KR)
- Eulji University (KR)
- Konkuk University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Kyungpook National University Hospital (KR)
- New Generation University College (ET)
- University Medical Center (US)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
- Daegu Catholic University (KR)
- University of Ulsan (KR)
- Chonnam National University Hospital (KR)
- Hallym University Kangnam Sacred Heart Hospital (KR)
- Konyang University Hospital (KR)
- Dongguk University Ilsan Hospital (KR)
- Inje University Busan Paik Hospital (KR)
- Pusan National University Hospital (KR)
- National University College (PR)
- Sejong General Hospital (KR)
- Jeonbuk National University Hospital (KR)
- Ulsan University Hospital (KR)
- Biomedical Research Institute (US)
- Gangneung Asan Hospital (KR)
- Myongji Hospital (KR)
- Gangnam Severance Hospital (KR)
- Yeungnam University Medical Center (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- National Health Insurance Service (KR)
- Chungbuk National University Hospital (KR)
- Yeungnam University College
- Dong-A University (KR)
- Keimyung University (KR)
- Yeungnam University (KR)
- Ajou University (KR)
- Bucheon University (KR)
- Chung-Ang University (KR)
- Jeonbuk National University (KR)
- Jeju National University (KR)
Publication Details
- Journal
- Endocrinology and Metabolism
- Published
- 2024-08-22
- DOI
- https://doi.org/10.3803/enm.2024.1995
- Citations
- 5
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Korean Diabetes Association
- National Health Insurance Service