Elevated C-Reactive Protein in Older Men With Chronic Pain: Association With Plasma Amyloid Levels and Hippocampal Volume
Chronic pain was associated with higher plasma Aβ, especially when hs-CRP was also elevated. Higher hs-CRP and Aβ levels were both related to smaller hippocampal volumes. Chronic pain, when accompanied by systemic inflammation, may elevate the risk of neurodegeneration in AD-vulnerable regions.
Authors
- Imanuel Lerman (ORCID: https://orcid.org/0000-0002-6564-7222)
- Tyler Bell (ORCID: https://orcid.org/0000-0001-5702-5995)
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- Lisa T. Eyler (ORCID: https://orcid.org/0000-0002-7783-8798)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- Olivia K. Puckett (ORCID: https://orcid.org/0000-0002-5073-2563)
- Mc Kenna E. Williams
- Michael J. Lyons (ORCID: https://orcid.org/0000-0001-6516-9219)
- Rahul C. Pearce
- Donald J. Hagler (ORCID: https://orcid.org/0000-0002-0331-3294)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Stephen M Dorros
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Matthew S. Panizzon
Institutions
- Boston University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1093/gerona/glae206
- Citations
- 6
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- U.S. Department of Veterans Affairs
- Alzheimer's Association
- National Institutes of Health