Association between tumor-infiltrating lymphocytes and survival in patients with metastatic breast cancer receiving first-line chemotherapy: analysis of CALGB 40502
Association of stromal tumor-infiltrating lymphocytes (sTILs) with survival outcomes among patients with metastatic breast cancer (MBC) remains unclear. The primary objective was to evaluate the association of sTILs with progression-free survival in randomized phase III trial CALGB 40502. sTILs were associated with progression-free and overall survival in chemotherapy-treated MBC when controlling for treatment arm; however, this effect did not remain significant after additional adjustment for hormone receptor status. CALGB is now part of the Alliance for Clinical Trials in Oncology. Trial Registration: ClinicalTrials.gov: NCT00785291.
Authors
- W. Fraser Symmans (ORCID: https://orcid.org/0000-0002-1526-184X)
- Mark A. Watson (ORCID: https://orcid.org/0000-0002-3935-9980)
- Sherene Loi (ORCID: https://orcid.org/0000-0001-6137-9171)
- Roberto Salgado (ORCID: https://orcid.org/0000-0002-1110-3801)
- Ann H. Partridge (ORCID: https://orcid.org/0000-0002-4722-4824)
- Oleksander Savenkov (ORCID: https://orcid.org/0000-0001-7890-0752)
- Daniel G. Stover (ORCID: https://orcid.org/0000-0001-9003-8165)
- Lisa A. Carey (ORCID: https://orcid.org/0000-0003-2388-4649)
- Yujia Wen (ORCID: https://orcid.org/0009-0000-5398-4494)
- Charles M. Perou (ORCID: https://orcid.org/0000-0001-9827-2247)
- Mark Jesus M. Magbanua (ORCID: https://orcid.org/0000-0003-2113-3593)
- Erica L. Mayer (ORCID: https://orcid.org/0000-0001-5430-8957)
- Karla V. Ballman (ORCID: https://orcid.org/0000-0002-4492-0357)
- Mark Vater
- Hope S. Rugo (ORCID: https://orcid.org/0000-0001-6710-4814)
- Kristyn Glover
Institutions
- University of North Carolina at Chapel Hill (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Peter MacCallum Cancer Centre (AU)
- University of Chicago (US)
- GZA Ziekenhuizen Campus Sint-Augustinus (BE)
- CancerCare (US)
- Dana-Farber/Harvard Cancer Center (US)
- UNC Lineberger Comprehensive Cancer Center
- The Ohio State University (US)
Publication Details
- Journal
- npj Breast Cancer
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1038/s41523-024-00683-x
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Breast Cancer Research Foundation
- Celgene
- National Institutes of Health
- National Cancer Institute