Estrogen Deficiency Exacerbates Traumatic Heterotopic Ossification in Mice
Estrogen deficiency exacerbated HO formation in the Achilles tenotomy model. These findings might be attributable to the disturbance of the inflammatory response and the activation of TGF-β/SMAD signaling at the injury sites during the early stages of HO development.
Authors
- Yifan Wu (ORCID: https://orcid.org/0000-0002-6179-0494)
- Wanrong Yi
- Aixi Yu (ORCID: https://orcid.org/0000-0002-5723-6140)
- Zonghuan Li (ORCID: https://orcid.org/0000-0002-7259-5360)
- Yifeng Yu (ORCID: https://orcid.org/0000-0002-3071-4798)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-1176-7659)
- Xue Fang (ORCID: https://orcid.org/0000-0002-4691-9878)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jir.s477382
- Citations
- 8
- Primary Topic
- Heterotopic Ossification and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.76