LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates epithelial-mesenchymal transition of peritoneal mesothelial cells and M2 macrophage polarization
Our study demonstrated that LCZ696 improves PF and ameliorates TGF-β1-induced EMT of HPMCs by blocking TGF-β/Smad3, PDGFRβ and EGFR pathways. Meanwhile, LCZ696 also inhibits M2 macrophage polarization by regulating STAT6 pathway.
Authors
- Xialin Li (ORCID: https://orcid.org/0000-0002-9955-5465)
- Shougang Zhuang (ORCID: https://orcid.org/0000-0001-9719-4187)
- Daofang Jiang (ORCID: https://orcid.org/0000-0003-2461-419X)
- Yingfeng Shi
- Yi Wang (ORCID: https://orcid.org/0000-0002-2109-2157)
- Na Liu (ORCID: https://orcid.org/0000-0001-9103-3227)
- Qin Zhong
- Yan Hu
- Jinqing Li (ORCID: https://orcid.org/0000-0002-8954-392X)
- Xiaoyan Ma (ORCID: https://orcid.org/0000-0003-0045-4320)
- Canxin Zhou (ORCID: https://orcid.org/0000-0002-7804-2134)
Institutions
- Brown University (US)
- Rhode Island Hospital (US)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1080/0886022x.2024.2392849
- Citations
- 4
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Shanghai Pudong New Area Health Commission