Characterization of the SARS-CoV-2 antibody landscape in Norway in the late summer of 2022: high seroprevalence in all age groups with patterns of primary Omicron infection in children and hybrid immunity in adults
By late summer of 2022, most of the Norwegian population had antibodies to SARS-CoV-2, and almost all children had been infected. Antibody profiles indicated that children mostly had experienced a primary Omicron infection, while hybrid immunity was common among adults. The finding that sera displaying hybrid immunity could neutralize newer Omicron variants indicates that Wuhan-like priming of the immune response did not have a harmful imprinting effect and that infections induce cross-reacting antibodies against future variants.
Authors
- Anna Hayman Robertson (ORCID: https://orcid.org/0000-0001-6295-0528)
- Elisabeth Lea Vikse
- Lill Trogstad (ORCID: https://orcid.org/0000-0002-9557-5725)
- Per Magnus (ORCID: https://orcid.org/0000-0002-6427-4735)
- Adity Chopra (ORCID: https://orcid.org/0000-0002-0838-1675)
- Fridtjof Lund‐Johansen (ORCID: https://orcid.org/0000-0002-2445-1258)
- John Torgils Vaage (ORCID: https://orcid.org/0000-0003-0988-5768)
- Anne‐Marte Bakken Kran (ORCID: https://orcid.org/0000-0003-3056-9137)
- Gro Tunheim (ORCID: https://orcid.org/0000-0002-8280-8243)
- Olav Hungnes (ORCID: https://orcid.org/0000-0003-1532-0130)
- Siri Mjaaland (ORCID: https://orcid.org/0000-0002-3870-5861)
- Even Fossum (ORCID: https://orcid.org/0000-0001-7064-0327)
- Gunnar Rø (ORCID: https://orcid.org/0000-0001-7545-788X)
Institutions
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s12879-024-09670-w
- Citations
- 10
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 3.89
Funders
- Haukeland Universitetssjukehus
- Akershus Universitetssykehus
- Sykehuset i Vestfold
- Norwegian Institute of Public Health