Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study
Our study provides valuable insights into the epigenetic consequences of COVID-19. Results suggest possible associations with accelerated aging, epigenetic drift, and the disruption of critical biological pathways linked to insulin resistance, immune response, and vascular health. Understanding these epigenetic changes could be crucial for elucidating the complex mechanisms behind long-COVID and developing targeted therapeutic interventions.
Authors
- Antonella Farsetti (ORCID: https://orcid.org/0000-0002-8603-7925)
- Gianfranco Parati (ORCID: https://orcid.org/0000-0001-9402-7439)
- Irene Campi (ORCID: https://orcid.org/0000-0002-0340-9923)
- Michela Gottardi Zamperla (ORCID: https://orcid.org/0000-0001-5948-9478)
- Francesco Ranucci
- Giulia Nicole Baldrighi (ORCID: https://orcid.org/0000-0001-8538-4768)
- Elvira Inglese (ORCID: https://orcid.org/0000-0002-8856-3558)
- Anna Maria Di Blasio (ORCID: https://orcid.org/0000-0001-6451-4156)
- Davide Gentilini (ORCID: https://orcid.org/0000-0002-8391-0725)
- Sara De Martino (ORCID: https://orcid.org/0000-0002-6226-4090)
- Rebecca Cavagnola (ORCID: https://orcid.org/0000-0001-6523-0104)
- Alberto Brusati (ORCID: https://orcid.org/0000-0003-0686-8030)
- Veronica Barbi (ORCID: https://orcid.org/0000-0001-9618-1368)
- Luca Persani (ORCID: https://orcid.org/0000-0003-2068-9581)
- Carlo Gaetano (ORCID: https://orcid.org/0000-0002-5238-1832)
- Luciano Calzari (ORCID: https://orcid.org/0000-0003-4283-0988)
- Romano Danesi (ORCID: https://orcid.org/0000-0002-4414-8934)
- Lucia Zanotti
- Davide Fernando Dragani
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Consorzio Roma Ricerche (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s13148-024-01724-9
- Citations
- 15
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- Ministero della Salute