Serum neurofilament light at diagnosis: a prognostic indicator for accelerated disease progression in Parkinson’s Disease
Neurofilament light chain (NFL) is elevated in neurodegenerative diseases, including Parkinson's disease (PD). This study aimed to investigate serum NFL in newly diagnosed PD and its association with cognitive and motor decline over 10 years. Serum NFL levels were measured in PD patients and controls from the ParkWest study at diagnosis (baseline) and after 3 and 5 years. Mixed-effects regression analyzed changes in NFL and the association with annual changes in MMSE and UPDRS-III scores over 10 years. PD patients had elevated serum NFL at all visits and a faster annual increase over 5 years compared to controls (0.09 pg/mL per year; p = 0.029). Higher baseline NFL predicted faster cognitive decline β -0.77 transformed MMSE; p = 0.010), and a 40% NFL increase predicted future motor decline (β 0.28 UPDRS-III; p = 0.004). Elevated serum NFL in early PD is linked to faster cognitive and motor impairment, suggesting its prognostic value in PD biomarker panels.
Authors
- Jodi Maple‐Grødem (ORCID: https://orcid.org/0000-0001-7142-0078)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Ole‐Bjørn Tysnes (ORCID: https://orcid.org/0000-0002-7230-6426)
- Camilla Christina Pedersen (ORCID: https://orcid.org/0000-0001-6521-741X)
- Guido Alves (ORCID: https://orcid.org/0000-0003-0630-2870)
- Johannes Lange (ORCID: https://orcid.org/0000-0003-0604-4891)
- Anastasia Ushakova (ORCID: https://orcid.org/0009-0004-9481-0932)
- Henrik Zetterberg
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- Stavanger University Hospital (NO)
- Haukeland University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- University of Bergen (NO)
- University College London (GB)
- University of Gothenburg (SE)
- University of Stavanger (NO)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1038/s41531-024-00768-1
- Citations
- 18
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.64
Funders
- Parkinson Research Foundation
- Universitetet i Stavanger
- Norges Forskningsråd
- Nasjonalforeningen for Folkehelsen