Von Willebrand factor exacerbates heart failure through formation of neutrophil extracellular traps
This study established the role of a novel VWF-SLC44A2-NET axis in regulating mitochondrial homeostasis and function, leading to cardiac apoptosis and contributing to HF pathogenesis. Targeting this axis may offer a potential therapeutic approach for HF treatment.
Authors
- Jingxuan Cui (ORCID: https://orcid.org/0000-0001-8738-4948)
- Dongni Wang (ORCID: https://orcid.org/0000-0002-7130-6408)
- Zhonghua Tong
- Huiqi Xie (ORCID: https://orcid.org/0000-0003-0760-0853)
- Yujia Chen (ORCID: https://orcid.org/0000-0003-4524-7982)
- Bo Yu (ORCID: https://orcid.org/0000-0002-2045-8567)
- Xiangyu Yan (ORCID: https://orcid.org/0009-0007-4602-105X)
- Ruishuang Ma (ORCID: https://orcid.org/0000-0003-4288-9883)
- Ge Mang (ORCID: https://orcid.org/0000-0003-3953-7000)
- Jingwen Du
- Qiannan Yang
- Jianfeng Chen (ORCID: https://orcid.org/0000-0002-4182-145X)
- Xiaoqi Wang
- Yingjin Kong (ORCID: https://orcid.org/0009-0005-4767-2474)
- Maomao Zhang (ORCID: https://orcid.org/0000-0001-5649-7931)
- Jiaqi Jin (ORCID: https://orcid.org/0000-0001-6275-4623)
- Ping Sun
- Mian Yang
- Jian Wu (ORCID: https://orcid.org/0000-0002-9523-5237)
Institutions
- Harbin Medical University (CN)
- Capital Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1093/eurheartj/ehae517
- Citations
- 31
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.46
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province
- National Postdoctoral Program for Innovative Talents