Factors Affecting an Increase in Spleen Volume and Association of Spleen Volume Variation with the Clinical Outcomes of Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma: A Retrospective Analysis
Caution is warranted to detect the aggravation of portal hypertension when administering Atez/Bev to young patients or patients with an impaired liver function or pretreatment spleen enlargement. The impact of spleen modulation by Atez/Bev appears to be limited on clinical efficacy.
Authors
- Hideko Ohama (ORCID: https://orcid.org/0000-0002-1882-824X)
- Joji Tani (ORCID: https://orcid.org/0000-0001-8801-2505)
- Tomomitsu Matono
- Kazuhito Kawata (ORCID: https://orcid.org/0000-0002-4986-8578)
- Kazuya Kariyama (ORCID: https://orcid.org/0000-0003-3996-7502)
- Hidenori Toyoda (ORCID: https://orcid.org/0000-0002-1652-6168)
- Kazuhiro Nouso (ORCID: https://orcid.org/0000-0002-2018-0008)
- Takeshi Hatanaka (ORCID: https://orcid.org/0000-0003-3656-285X)
- Atsushi Hiraoka (ORCID: https://orcid.org/0000-0003-1989-0480)
- Takashi Kumada (ORCID: https://orcid.org/0000-0003-2211-495X)
- Takuya Nagano (ORCID: https://orcid.org/0000-0003-1043-8033)
- Ei Itobayashi (ORCID: https://orcid.org/0000-0003-0475-2819)
- Toshifumi Tada (ORCID: https://orcid.org/0000-0002-0976-6761)
- Atsushi Naganuma (ORCID: https://orcid.org/0000-0003-0663-0102)
- Akemi Tsutsui (ORCID: https://orcid.org/0000-0003-2978-2723)
- Toru Ishikawa (ORCID: https://orcid.org/0000-0002-5470-9694)
- Satoru Kakizaki (ORCID: https://orcid.org/0000-0002-1508-584X)
- Yutaka Yata (ORCID: https://orcid.org/0000-0002-4592-3509)
- Fujimasa Tada (ORCID: https://orcid.org/0009-0007-3964-5876)
- Asahiro Morishita (ORCID: https://orcid.org/0000-0002-0760-3045)
- Koichi Takaguchi (ORCID: https://orcid.org/0000-0003-0175-8721)
- Naoto Saito (ORCID: https://orcid.org/0000-0001-6424-087X)
- Shinichiro Nakamura (ORCID: https://orcid.org/0009-0001-5065-9669)
Institutions
- Gunma University (JP)
- Kagawa University (JP)
- Hamamatsu University School of Medicine (JP)
- Saiseikai Niigata Daini Hospital (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Okayama Prefecture (JP)
- Ogaki Municipal Hospital (JP)
- Himeji Medical Center (JP)
- Hanwa Memorial Hospital (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Himeji Red Cross Hospital (JP)
- Asahi General Hospital (JP)
- Ehime Prefectural Central Hospital (JP)
- Kagawa Prefectural Central Hospital (JP)
- Takarazuka City Hospital (JP)
- Gifu Kyoritsu University (JP)
Publication Details
- Journal
- Oncology
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1159/000541002
- Citations
- 4
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.48