Joint estimation of compartment‐specific <scp><i>T</i><sub>2</sub></scp> relaxation and tumor microstructure using multi‐TE IMPULSED MRI
The findings from this study highlight two key observations: (i) TE has a negligible impact on IMPULSED-derived cell sizes, and (ii) the TE-dependence of IMPULSED-derived intracellular volume fractions used in T<sub>2</sub> + IMPULSED modeling to estimate <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow><mml:msubsup><mml:mi>T</mml:mi> <mml:mn>2</mml:mn> <mml:mtext>in</mml:mtext></mml:msubsup> </mml:mrow> <mml:annotation>$$ {T}_2^{in} $$</mml:annotation></mml:semantics> </mml:math> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow><mml:msubsup><mml:mi>T</mml:mi> <mml:mn>2</mml:mn> <mml:mi>ex</mml:mi></mml:msubsup> </mml:mrow> <mml:annotation>$$ {T}_2^{ex} $$</mml:annotation></mml:semantics> </mml:math> . These insights contribute to the ongoing development and refinement of non-invasive MRI techniques for measuring cell sizes.
Authors
- Xiaoyu Jiang (ORCID: https://orcid.org/0000-0002-0369-6301)
- John C. Gore (ORCID: https://orcid.org/0000-0002-9480-0900)
- Junzhong Xu (ORCID: https://orcid.org/0000-0001-7895-4232)
- Kevin D. Harkins (ORCID: https://orcid.org/0000-0003-3579-9273)
- Zhongliang Zu (ORCID: https://orcid.org/0000-0001-7361-7480)
- Jian Wang (ORCID: https://orcid.org/0000-0003-2093-5789)
- Jingping Xie
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1002/mrm.30254
- Citations
- 6
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.43
Funders
- National Institutes of Health