The deubiquitinase USP15 drives malignant progression of gastric cancer through glucose metabolism remodeling
Our study unveiled aberrantly high expression of USP15 in GC tissues, correlating with malignant progression and nonresponse to neoadjuvant therapy. USP15 inhibitors, if developed, could be effective in promoting chemotherapy through glucose metabolism remodeling.
Authors
- Longtao Huangfu (ORCID: https://orcid.org/0000-0003-4185-2747)
- Junbing Chen (ORCID: https://orcid.org/0000-0002-5741-1332)
- Hong Du (ORCID: https://orcid.org/0000-0002-1107-2902)
- Qian Yao (ORCID: https://orcid.org/0000-0002-4581-5989)
- Huanbo Zhu (ORCID: https://orcid.org/0009-0001-5104-9467)
- Gangjian Wang (ORCID: https://orcid.org/0000-0002-3054-7205)
- Xiaoyang Wang (ORCID: https://orcid.org/0000-0001-9717-8160)
- Ting Guo (ORCID: https://orcid.org/0000-0003-0199-5639)
- Xiaomei Li (ORCID: https://orcid.org/0000-0002-4449-9611)
- Yongqi Wang (ORCID: https://orcid.org/0000-0003-2894-5471)
- Xiaofang Xing (ORCID: https://orcid.org/0000-0002-9576-995X)
- Ying Hu (ORCID: https://orcid.org/0009-0000-3175-3388)
- Jiafu Ji (ORCID: https://orcid.org/0000-0002-0486-5445)
- Biao Fan (ORCID: https://orcid.org/0000-0002-5585-9993)
- Jing Han (ORCID: https://orcid.org/0000-0003-0048-2241)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s13046-024-03152-2
- Citations
- 9
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China
- Peking University