Targeting the I <sub>Ks</sub> Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants

Our findings not only elucidate the molecular mechanism of PKA-dependent I<sub>Ks</sub> channel phosphorylation but also provide an effective antiarrhythmic strategy for patients with high-risk LQT1 variants.

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Publication Details

Journal
Circulation Research
Published
2024-08-22
DOI
https://doi.org/10.1161/circresaha.124.325009
Citations
8
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
3.22

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Targeting the I Ks Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants

Xinjiang Kang, Bing Shen, Yue Ouyang, Panpan Hou et al.
8 citations
Circulation Research
Cardiac electrophysiology and arrhythmias
3.22
article

Targeting the I Ks Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants

Xinjiang Kang, Bing Shen, Yue Ouyang, Panpan Hou, Jonathan R. Silva, Changhe Wang, Erwin Neher, Zhi‐Hong Jiang, Wandi Zhu, Dexiang Jiang, Jing Yao, Kuo‐Chan Weng, Chen Huang, Huaiyu Yang, Ling Zhong, Xiaoqing Lin, Zhenzhen Yan, Sookja Kim Chung, Hangyu Zhang, Chenxin Xiao
article en
8 citations

Abstract

Our findings not only elucidate the molecular mechanism of PKA-dependent I<sub>Ks</sub> channel phosphorylation but also provide an effective antiarrhythmic strategy for patients with high-risk LQT1 variants.

Circulation ResearchVol. 135(7)
Macau University of Science and Technology (MO), Brigham and Women's Hospital (US), Liaocheng University (CN), Southwest Medical University (CN), Affiliated Hospital of Southwest Medical University (CN), Wuhan Institute of Virology (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Texas Cardiac Arrhythmia (US), Hi-Z Technology (United States) (US), East China Normal University (CN)
Technische Universität München, Macau University of Science and Technology, National Institutes of Health
Openalex Percentile: Top 7%
Cardiac electrophysiology and arrhythmias
3.22
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