Targeting the I <sub>Ks</sub> Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants
Our findings not only elucidate the molecular mechanism of PKA-dependent I<sub>Ks</sub> channel phosphorylation but also provide an effective antiarrhythmic strategy for patients with high-risk LQT1 variants.
Authors
- Xinjiang Kang (ORCID: https://orcid.org/0000-0003-0877-2438)
- Bing Shen (ORCID: https://orcid.org/0000-0001-7263-4748)
- Yue Ouyang (ORCID: https://orcid.org/0000-0001-7735-5334)
- Panpan Hou (ORCID: https://orcid.org/0000-0001-7694-2262)
- Jonathan R. Silva (ORCID: https://orcid.org/0000-0002-3696-3955)
- Changhe Wang (ORCID: https://orcid.org/0000-0002-5902-2277)
- Erwin Neher (ORCID: https://orcid.org/0000-0002-9758-7922)
- Zhi‐Hong Jiang (ORCID: https://orcid.org/0000-0002-7956-2481)
- Wandi Zhu (ORCID: https://orcid.org/0000-0003-0927-5687)
- Dexiang Jiang
- Jing Yao (ORCID: https://orcid.org/0000-0003-1844-3988)
- Kuo‐Chan Weng (ORCID: https://orcid.org/0000-0002-0549-755X)
- Chen Huang (ORCID: https://orcid.org/0000-0002-7092-7587)
- Huaiyu Yang (ORCID: https://orcid.org/0000-0003-2358-1840)
- Ling Zhong
- Xiaoqing Lin (ORCID: https://orcid.org/0009-0003-1376-4245)
- Zhenzhen Yan (ORCID: https://orcid.org/0000-0002-4416-9743)
- Sookja Kim Chung (ORCID: https://orcid.org/0000-0002-0666-9827)
- Hangyu Zhang
- Chenxin Xiao (ORCID: https://orcid.org/0009-0007-4702-9539)
Institutions
- Macau University of Science and Technology (MO)
- Brigham and Women's Hospital (US)
- Liaocheng University (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Wuhan Institute of Virology (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Texas Cardiac Arrhythmia (US)
- Hi-Z Technology (United States) (US)
- East China Normal University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1161/circresaha.124.325009
- Citations
- 8
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Technische Universität München
- Macau University of Science and Technology
- National Institutes of Health