Intravenous infusions of mesenchymal stromal cells have cumulative beneficial effects in a porcine model of chronic ischaemic cardiomyopathy
To our knowledge, this is the first study to show that intravenous infusion of a cell product improves LV function and structure in a large animal model of chronic ischaemic cardiomyopathy and that repeated infusions are necessary to produce robust effects. This study, conducted in a clinically relevant model, supports a new therapeutic strategy based on repeated intravenous infusions of allogeneic MSCs and provides a foundation for a first-in-human trial testing this strategy in patients with chronic ischaemic cardiomyopathy.
Authors
- Xian‐Liang Tang (ORCID: https://orcid.org/0000-0002-5987-340X)
- Marcin Wysoczynski (ORCID: https://orcid.org/0000-0001-6319-2386)
- Roberto Bolli (ORCID: https://orcid.org/0000-0002-9160-8614)
- Ján Slezák (ORCID: https://orcid.org/0000-0002-4217-4493)
- Mitesh Solanki (ORCID: https://orcid.org/0000-0002-3216-8401)
- Shirong Zheng
- Qinghui Ou
- Nida Tanveer
- Anna M. Gumpert
- Heather Stowers
- Hong Li (ORCID: https://orcid.org/0000-0001-9984-3849)
- Yan Li (ORCID: https://orcid.org/0000-0003-0096-0813)
- Shengnan Zheng
- Halina Ruble
- Wen-Jian Wu
- Dinesh Kalra
Institutions
- University of Louisville (US)
- Art Research Centre of the Slovak Academy of Sciences (SK)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1093/cvr/cvae173
- Citations
- 11
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.82
Funders
- U.S. Department of Defense
- Norges Idrettshøgskole