Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
These results support that the PU.1-IL-9 axis forms a positive loop in Th9 dysregulation of RA. Targeting this signalling axis presents a potential target approach for treating RA.
Authors
- Weile Chen (ORCID: https://orcid.org/0009-0001-6209-8504)
- Wei Huang (ORCID: https://orcid.org/0000-0002-2513-1993)
- Lingling Zhang (ORCID: https://orcid.org/0000-0001-5070-8523)
- Xuming Wu
- Dafei Han
- Yuanyuan Zhou (ORCID: https://orcid.org/0000-0002-8364-4295)
- Jiajie Tu (ORCID: https://orcid.org/0000-0002-3895-3726)
- Zimeng Xue
- Yilong Fang (ORCID: https://orcid.org/0009-0008-5596-0849)
- Wei Wei (ORCID: https://orcid.org/0000-0002-3117-9598)
- Huihui Wang (ORCID: https://orcid.org/0000-0001-5781-0504)
- Chong Liu (ORCID: https://orcid.org/0000-0002-0091-0130)
- Zhu Chen (ORCID: https://orcid.org/0000-0002-9974-0716)
- Xinming Wang (ORCID: https://orcid.org/0000-0002-1982-0928)
- Yujie Deng
- Zhenbao Li (ORCID: https://orcid.org/0000-0002-9751-2170)
- Shangxue Yan (ORCID: https://orcid.org/0000-0001-8780-4279)
- Yizhao Chen
- Chunlan Yang
- Anqi Wang (ORCID: https://orcid.org/0000-0001-5606-3033)
- Hui Xue
- Huiru Zhang (ORCID: https://orcid.org/0000-0002-9030-1514)
- Xiangling Zhu
- Shihao Zhang
- Xuewen Tan
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1136/ard-2024-226067
- Citations
- 19
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 4.57
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- Natural Science Foundation of Anhui Province