Microneedle-Mediated Delivery of siRNA via Liposomal-Based Transfection for Inner Ear Gene Therapy
Small volumes of siRNA and Lipofectamine can be effectively delivered to cochlear structures using microneedles, paving the way for atraumatic cochlear gene therapy.
Authors
- François Voruz (ORCID: https://orcid.org/0000-0003-2774-5507)
- Michelle Yu (ORCID: https://orcid.org/0000-0002-3131-5510)
- Elizabeth S. Olson
- Stephen Leong (ORCID: https://orcid.org/0000-0002-6833-5072)
- Sharon J. Feng (ORCID: https://orcid.org/0000-0001-6935-4075)
- Aykut Aksit (ORCID: https://orcid.org/0000-0003-4565-1205)
- Jeffrey W. Kysar (ORCID: https://orcid.org/0000-0003-3655-1077)
- Lauren A. Chiriboga
- Anil K. Lalwani (ORCID: https://orcid.org/0000-0001-8635-8473)
- Eugénie Breil
- Daniella R Hammer
Institutions
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- Cochlear (United States) (US)
- Columbia University (US)
Publication Details
- Journal
- Otology & Neurotology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1097/mao.0000000000004297
- Citations
- 5
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.81