Cortisol/Cortisone Ratio in Youth with Obesity One Year Following Sleeve Gastrectomy

<b><i>Background:</i></b> Glucocorticoid metabolites are associated with body composition measures and are altered with weight status. Metabolic and bariatric surgery (MBS) results in significant changes in weight and body composition. However, MBS effects on glucocorticoid metabolites are unknown. <b><i>Objective:</i></b> To evaluate (i) changes in the cortisol/cortisone ratio in youth with obesity 12 months after sleeve gastrectomy (SG) compared with nonsurgical controls with obesity (NS), and (ii) associations of these changes with body composition changes. <b><i>Methods:</i></b> A total of 38 participants 13-25 years old with obesity (29 female) were followed for 12 months. Half underwent SG, and the other half were followed with routine care (nonsurgical, NS). Fasting blood was assessed for cortisol and cortisone using liquid chromatography-mass spectroscopy as part of metabolomic analysis, and the cortisol/cortisone ratio was calculated. A single-slice MRI of the abdomen was performed to assess subcutaneous and visceral adipose tissue (SAT, VAT<u>)</u>. Hepatic steatosis was assessed by computed tomography (CT). <b><i>Results:</i></b> SG did not differ from NS for baseline clinical characteristics, other than the mean age (SG 18.0 ± 0.46 vs. NS 16.6 ± 0.50 years, <i>P</i> = 0.041), BMI (BMI, 47.23 ± 1.5 vs. 41.32 ± 1.1 kg/m², <i>P</i> = 0.003) weight and VAT, which were higher in SG. Significant reductions were noted over 12 months in BMI, BMI z-score, VAT, and SAT within the SG versus NS groups (<i>P</i> ≤ 0.001). Over 12 months, groups did not differ for changes in cortisol/cortisone ratio after controlling for age at baseline (<i>P</i> = 0.293). The ratio trended to decrease within the SG group [-1.40 (-5.08, 0.06), <i>P</i> = 0.080], particularly among those that had completed puberty (<i>P</i> = 0.048). No associations were found between changes in the cortisol/cortisone ratio and changes in body composition. <b><i>Conclusions:</i></b> The cortisol/cortisone ratio trended to decrease 12 months following SG. However, no associations were found between changes in the cortisol/cortisone ratio and changes in body composition. Studies with larger numbers of participants are necessary to confirm these findings.