Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis
Circ-0034880-enriched TEVs facilitate strong interaction between primary tumor cells and SPP1<sup>high</sup>CD206<sup>+</sup> pro-tumor macrophages, promoting PMN formation and CRLM. These findings suggest the potential of using Ginsenoside Rb1 as an alternative therapeutic agent to reshape PMN formation and prevent CRLM.
Authors
- Yuqing Song
- Yunzhou Pu
- Qing Ji (ORCID: https://orcid.org/0000-0002-1899-0204)
- Yicun Han
- Guanghao Zhu
- Xiaodie Liu (ORCID: https://orcid.org/0000-0002-9884-7335)
- Ziyuan Wang (ORCID: https://orcid.org/0000-0001-6336-0300)
- Liu Yang (ORCID: https://orcid.org/0000-0002-0685-7203)
- Haoze Li (ORCID: https://orcid.org/0000-0003-0463-7335)
- Jian Sun (ORCID: https://orcid.org/0000-0001-9645-4741)
- Huirong Zhu (ORCID: https://orcid.org/0000-0002-2733-3978)
- Guangbo Ge (ORCID: https://orcid.org/0000-0002-8437-9155)
- Qing Song (ORCID: https://orcid.org/0000-0002-9773-1517)
- Hongshan Li (ORCID: https://orcid.org/0000-0002-9556-3556)
- Ling Li (ORCID: https://orcid.org/0000-0001-7293-6228)
- Wenqing Rong
- Xueyan Hu (ORCID: https://orcid.org/0009-0000-2462-6815)
- Jing Zhou (ORCID: https://orcid.org/0000-0003-4076-4083)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Ningbo No. 2 Hospital (CN)
- Shuguang Hospital (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s12943-024-02086-9
- Citations
- 43
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 10.05
Funders
- Memorial Sloan-Kettering Cancer Center
- National Natural Science Foundation of China
- Shanghai University of Traditional Chinese Medicine
- Natural Science Foundation of Ningbo
- Postdoctoral Research Foundation of China
- Natural Science Foundation of Zhejiang Province