Correlation Between Serum and CSF Concentrations of Midazolam and 1-Hydroxy-Midazolam in Critically Ill Neurosurgical Patients
Continuous infusions of MZ result in measurable concentrations of MZ and 1-OH-MZ in CSF; however, CSF concentrations of MZ and 1-OH-MZ poorly represent serum concentrations or dosages. Accumulation of MZ and 1-OH-MZ in serum or CSF over time was not evident. Concentrations of MZ and 1-OH-MZ do not predict sedation levels, reinforcing that pharmacodynamic assessments are warranted.
Authors
- Paul Reynolds (ORCID: https://orcid.org/0000-0002-7159-0517)
- Luis Cava
- Deb Sherman
- Robert MacLaren (ORCID: https://orcid.org/0000-0002-3569-5506)
- Julie E. Farrar (ORCID: https://orcid.org/0000-0003-1144-4806)
- Scott W. Mueller (ORCID: https://orcid.org/0000-0003-1238-8199)
- Tyree H. Kiser (ORCID: https://orcid.org/0000-0001-7415-3999)
- Sylvia S. Stefanos (ORCID: https://orcid.org/0000-0002-5042-1095)
- Robert Neumann
Institutions
- University of Colorado Hospital (US)
- University of Tennessee Health Science Center (US)
- Denver VA Medical Center (US)
- Methodist Hospital (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Annals of Pharmacotherapy
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1177/10600280241271130
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00