Variability in morphology and immunohistochemistry of Crohn’s disease-associated small bowel neoplasms: implications of Claudin 18 and Cadherin 17 expression for tumor-targeted immunotherapies
In CD-associated small bowel adenocarcinomas, Cadherin 17 expression was frequently retained and Claudin 18 was frequently co-expressed. Claudin 18 had a positive correlation with the expression of gastric mucins. These results suggest that CD-associated small bowel adenocarcinomas may be candidates for Cadherin 17- and Claudin 18-targeted immunotherapies.
Authors
- Keiko Abe (ORCID: https://orcid.org/0000-0001-5844-8199)
- Robert H. Riddell (ORCID: https://orcid.org/0000-0002-5318-9770)
- Mai Iwaya (ORCID: https://orcid.org/0000-0003-2135-2219)
- Hiroyoshi Ota (ORCID: https://orcid.org/0000-0003-0592-239X)
- Risa Nishio
- Takeshi Uehara (ORCID: https://orcid.org/0000-0002-7694-9015)
- Makoto Kodama (ORCID: https://orcid.org/0000-0002-4969-8249)
- Tomoyuki Nakajima (ORCID: https://orcid.org/0009-0004-3144-7558)
- Tetsuo Yamana
- K. Maeda
Institutions
- Mount Sinai Hospital (CA)
- Shinshu University (JP)
- University of Toronto (CA)
- Shinshu University Hospital (JP)
- Tokyo Yamate Medical Center (JP)
Publication Details
- Journal
- Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1007/s00428-024-03896-4
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- Shinshu University
- Japan Society for the Promotion of Science