EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
Enhanced therapeutic efficacy and robust anti-tumorigenic immune response of Apt-2cNP in the CRC-TME are promising indicators of its potential as a prospective therapeutic agent for managing CRC. However, further studies are warranted.
Authors
- Benny Abraham Kaipparettu (ORCID: https://orcid.org/0000-0003-3444-4307)
- Priyanka Boro
- Mohiuddin Abdul Quadir (ORCID: https://orcid.org/0000-0003-2811-773X)
- Soumik Laha (ORCID: https://orcid.org/0000-0003-3954-0293)
- Ashique Al Hoque (ORCID: https://orcid.org/0000-0002-0220-3982)
- Jun Hyoung Park
- Soumyabrata Banerjee
- Nayim Sepay (ORCID: https://orcid.org/0000-0001-7702-3989)
- Debasmita Dutta (ORCID: https://orcid.org/0000-0003-0235-4649)
- Biswajit Mukherjee (ORCID: https://orcid.org/0000-0002-7854-9680)
- Brahamacharry Paul (ORCID: https://orcid.org/0000-0001-7610-7822)
- Chinmay Chowdhury (ORCID: https://orcid.org/0000-0002-4230-3531)
- Arghadip Choudhury
Institutions
- Harvard University (US)
- Indian Institute of Chemical Biology (IN)
- Central Michigan University (US)
- Jadavpur University (IN)
- Baylor College of Medicine (US)
- Vidyasagar University (IN)
- Dana-Farber Cancer Institute (US)
- Baylor Genetics (US)
- North Dakota State University (US)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s12929-024-01069-8
- Citations
- 13
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Department of Biotechnology, Ministry of Science and Technology, India