Syndecan 4 is a marker of endothelial inflammation in pathological aging and predicts long-term cardiovascular outcomes in type 2 diabetes
Overall, we conclude that the shedding of SDC4 from endothelial cells increases under acute (TNF-α treatment) and chronic (senescence) inflammatory conditions and that increased circulating SDC4 levels are associated with systemic inflammation in pathological aging.
Authors
- Anna Rita Bonfigli (ORCID: https://orcid.org/0000-0002-9619-0181)
- Maria Rita Rippo (ORCID: https://orcid.org/0000-0003-3024-3495)
- Jacopo Sabbatinelli (ORCID: https://orcid.org/0000-0001-9947-6778)
- Matilde Sbriscia (ORCID: https://orcid.org/0000-0001-8058-9457)
- Olivieri Fabiola (ORCID: https://orcid.org/0000-0002-9606-1144)
- Giuseppina Rose (ORCID: https://orcid.org/0000-0002-4264-4184)
- Angelica Giuliani (ORCID: https://orcid.org/0000-0002-8477-8519)
- Deborah Ramini (ORCID: https://orcid.org/0000-0001-8925-8195)
- Paolina Crocco (ORCID: https://orcid.org/0000-0001-7803-5340)
- María De Luca (ORCID: https://orcid.org/0000-0001-6345-7508)
- Luca Tiano (ORCID: https://orcid.org/0000-0002-7519-7106)
Institutions
- Marche Polytechnic University (IT)
- University of Alabama at Birmingham (US)
- Istituti Clinici Scientifici Maugeri (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- University of Calabria (IT)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s13098-024-01431-8
- Citations
- 11
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Ministero della Salute
- Università Politecnica delle Marche