Efficient Synthesis and Iodine‐Functionalization of Pyrazoles <i>via</i> KIO<sub>3</sub>/PhSeSePh System under Acidic Conditions
This manuscript reports a novel method for the direct iodination of the C-4 pyrazole ring generated in situ by the reaction of 1,1,3,3-tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO<sub>3</sub>) is used as the iodinating agent and (PhSe)<sub>2</sub> is used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4-iodo-1-aryl-1H-pyrazoles, valuable intermediates for several different coupling reactions.
Authors
- Thiago J. Peglow (ORCID: https://orcid.org/0000-0001-6961-6047)
- Claudio Santi (ORCID: https://orcid.org/0000-0002-7698-8970)
- Patrick C. Nobre (ORCID: https://orcid.org/0000-0003-2050-2684)
- Cecilia Scimmi (ORCID: https://orcid.org/0000-0002-6967-1641)
- Vanessa Nascimento (ORCID: https://orcid.org/0000-0001-9413-7638)
- João Pedro S. S. C. Thomaz
Institutions
- Universidade Federal Fluminense (BR)
- University of Perugia (IT)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1002/asia.202400749
- Citations
- 5
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Instituto Nacional de Ciência e Tecnologia de Catálise em Sistemas Moleculares e Nanoestruturados