Spatial transcriptomics profiling of gallbladder adenocarcinoma: a detailed two-case study of progression from precursor lesions to cancer
Gallbladder adenocarcinoma can develop according to patient-specific processes, and limited intra-patient variability of precursor and cancer lesions was noticed. Our data suggest that repression of SEMA4A can promote tumour progression. They also highlight the need to gain gene expression data in addition to histological information to avoid understimating the risk of low-grade preneoplastic lesions.
Authors
- Sabine Cordi
- Catherine Hubert (ORCID: https://orcid.org/0000-0001-6837-2511)
- Selda Aydın
- Sébastien Toffoli
- Axelle E. Loriot (ORCID: https://orcid.org/0000-0002-5288-8561)
- Sophie Pirenne
- Frédéric P. Lemaigre (ORCID: https://orcid.org/0000-0002-3609-434X)
- Fátima Manzano‐Núñez (ORCID: https://orcid.org/0000-0001-9780-1792)
- Mina Komuta (ORCID: https://orcid.org/0000-0002-3999-1417)
- Christine Sempoux (ORCID: https://orcid.org/0000-0003-1375-3979)
- Lieven Desmet (ORCID: https://orcid.org/0000-0002-2459-7783)
- Laurent Gatto (ORCID: https://orcid.org/0000-0002-1520-2268)
- Nisha Limaye (ORCID: https://orcid.org/0000-0002-9820-4794)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Institute of Pathology and Genetics (BE)
- de Duve Institute (BE)
- International University of Health and Welfare (JP)
- UCLouvain (BE)
- University of Lausanne (CH)
- KU Leuven (BE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s12885-024-12770-0
- Citations
- 5
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Philipps-Universität Marburg
- Fonds De La Recherche Scientifique - FNRS
- Fonds Joseph Maisin
- Fondation contre le Cancer